Nano-metal oxides induce antimicrobial resistance via radical-mediated mutagenesis

Nano-Composite Metal Oxides for Electronic Noses

This program aims at producing the next generation of molecular chemical and biological sensors [1]. Is is an interdisciplinary effort to manufacture electronic "noses" from arrays of nanostructured metal oxide sensors, each of which is specific to a given gas. Specificity in nanostructured oxides is achieved by exploiting their structure sensitivity. The ongoing research focuses on the study o...

Tailoring nano-catalysts: turning gold nanoparticles on bulk metal oxides to inverse nano-metal oxides on large gold particles.

Highly active/stable inverse catalysts of nano-oxides on large gold particles are designed and tailored. For the gas-phase oxidation of alcohols as a model reaction, the experimental and theoretical results verify that the catalyst activity depends on the gold-oxide interface, and the anti-sintering feature of such an inverse structure endows the catalyst with high stability.

The Synthesis of Nano-Crystalline Metal Oxides by Solution Method

Efflux-mediated antimicrobial resistance.

Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease. And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of reduced biocide susceptibility are common and the history of antibiotic resistance should not be ignored in the development and use of biocidal agents. Efflux mechanisms of resistance, both drug specific and multidru...

Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis.

Antibiotic resistance arises through mechanisms such as selection of naturally occurring resistant mutants and horizontal gene transfer. Recently, oxidative stress has been implicated as one of the mechanisms whereby bactericidal antibiotics kill bacteria. Here, we show that sublethal levels of bactericidal antibiotics induce mutagenesis, resulting in heterogeneous increases in the minimum inhi...